Hemostasis and Thrombosis : Basic Principles and Clinical Pr > Hematology. Oncology

This superb text features internationally recognized authorities; full coverage of both hemostasis and thrombosis; detailed treatment of vessel wall physiology; integration of basic science information with clinical management specifics; nearly 15,000 references; extensive cross-referencing and much more. New to this edition: coverage of molecular genetics of hemostatic proteins, tissue factor pathway of blood coagulation, wound healing and angiogenesis, pathogenesis of atherosclerosis, hemostatic abnormalities in AIDS, treatment of venous thromboembolism, thrombolytic therapy for coronary artery disease, anticoagulant therapy with common agents and mechanisms of action of antiplatelet drugs. This edition also includes 150 new illustrations and tables

Part I Basic Principles of Hemostasis and Thrombosis
1. Overview of Hemostasis 3
Section A Plasma Factors and Inhibitors: Procoagulants and Fibrinolytic Proteins
2. Overview of Coagulation, Fibrinolysis, and Their Regulation 17
3. Blood Coagulation Factors: Their Complementary DNAs, Genes, and Expression 21
4. Genetic Principles Underlying Disorders of Procoagulant and Anticoagulant Proteins 59
5. Tissue Factor and Factor VII Initiation of Coagulation 89
6. Contact Activation Pathway: Inflammatory, Fibrinolytic, Anticoagulant, Antiadhesive, and Antiangiogenic Activities 103
7. Molecular Biology of Factor IX 123
8. Factor VIII and Hemophilia A 135
9. Factor V 157
10. Thrombin 171
11. Factor XI 191
12. Fibrinogen Structure and Physiology 203
13. Structure and Function of Factor XIII 233
14. Structure and Function of von Willebrand Factor 249
15. Plasminogen-Plasmin Enzyme System 275
16. Antithrombin III and Heparin Cofactor II 321
17. Protein C, Protein S, and Thrombomodulin 335
18. Plasminogen Activator Inhibitors 355
19. [alpha]-Macroglobulins and Kunins 367
Section B Platelets
20. Overview of Platelet Structure and Function 381
21. Megakaryocytopoiesis 387
22. Platelets and Megakaryocytes: Anatomy and Structural Organization 411
23. Platelet Cytoskeleton 429
24. Platelet Kinetics and Pathophysiology of Thrombocytopenia 447
25. Platelet Immunology 461
26. Integrin [alpha subscript IIb beta subscript 3] and Platelet Aggregation 479
27. Platelet Glycoprotein Ib-IX-V Complex and Platelet Adhesion 493
28. Platelet Stimulatory and Inhibitory Receptors 505
29. Platelet and Megakaryocyte Lipids 521
30. Platelet Eicosanoids 533
31. Platelet Signal Transduction 541
32. Platelet Secretion 561
33. Role of Platelets and Leukocytes in Coagulation 575
Section C Vessel Wall (Endothelial Cells: Structure and Function)
34. Development of the Vascular System 597
35. Endothelial Cell Biology 615
36. Rheology of Thrombosis 625
37. Adhesive Interactions of Blood Cells and the Vascular Wall in Hemostasis and Thrombosis 639
38. Interaction of Blood with Artificial Surfaces 661
39. Nitric Oxide and the Vessel Wall 673
40. Platelet-Vessel Wall Interactions in Flowing Blood 683
Section D Vessel Wall Structure and Function
41. Human Endothelial Cell Plasmin-Generating System 699
42. The Heparin/Antithrombin System: a Natural Anticoagulant Mechanism 711
43. Vascular Adaptations to Altered Blood Flow 733
44. Thrombosis and Atherosclerosis 743
45. Vessel Wall Metabolism of Lipids 753
46. Vascular Response to Injury 763
47. Angiogenesis and Vascular Morphogenesis 771
Part II Clinical Applications
Section A Hemorrhagic Disorders: Basic Concepts
48. Approach to the Bleeding Patient 783
49. Therapy with Antifibrinolytic Agents 795
Section B Inherited Hemorrhagic Disorders
50. Clinical Manifestations and Therapy of the Hemophilias 815
51. von Willebrand Disease: Diagnosis, Classification, and Treatment 825
52. Inherited Disorders of Prothrombin Conversion 839
53. Dysfibrinogenemia and Other Disorders of Fibrinogen Structure or Function 855
54. Congenital Disorders of Platelet Secretion and Signal Transduction 893
55. Acquired Qualitative Platelet Defects 905
56. Inherited Abnormalities of the Platelet Membrane: Glanzmann Thrombasthenia, Bernard-Soulier Syndrome, and Other Disorders 921
57. Primary Vascular Disorders 945
Section C Acquired Hemorrhagic Disorders
58. Hemostatic Abnormalities in Liver and Renal Disease 955
59. Physiologic Regulation and Pathologic Disorders of Fibrinolysis 975
60. Immune Coagulation Disorders 1003
61. Diagnosis and Management of Thrombocytopenia 1021
62. Hemostatic Problems in Surgical Patients 1031
63. Hemorrhagic Complications in the Obstetric Patient 1045
64. Hemorrhagic and Thromboembolic Complications during Infancy and Childhood 1053
Section D Thrombotic Disorders: Basic Concepts
65. Overview of Thrombosis and Its Treatment 1071
66. Approach to the Thrombophilic Patient 1085
67. Laboratory Markers of Platelet Activation 1101
68. Laboratory Markers of Coagulation and Fibrinolysis 1113
69. Abnormalities of Hemostasis in Malignancy 1131
70. Epidemiology, Pathogenesis, and Natural History of Venous Thrombosis 1153
71. Epidemiology of Arterial Thrombosis 1179
Section E Inherited and Acquired Thrombotic Disorders
72. Consumptive Thrombohemorrhagic Disorders 1197
73. Thrombotic Thrombocytopenic Purpura--Hemolytic-Uremic Syndrome 1235
74. Hereditary and Acquired Thrombophilic Syndromes 1243
75. Diagnosis of Venous Thrombosis 1277
76. Diagnosis of Pulmonary Embolism 1303
77. Valvular Heart Disease, Heart Valve Replacement, and Atrial Fibrillation 1317
78. Left Ventricular Thrombosis and Systemic Emboli in Myocardial Infarction and Cardiomyopathy 1325
79. Antiphospholipid Antibodies and the Antiphospholipid Syndrome 1339
Section F Therapy, New Directions, and Complications in Thrombotic Disorders
80. Hemorrhagic Complications of Anticoagulant Treatment 1357
81. Thrombotic Complications of Anticoagulant Therapy 1371
82. Thrombotic Complications of Pregnancy and Estrogen-Containing Preparations 1383
83. Prevention of Venous Thromboembolism 1393
84. Treatment of Venous Thromboembolism 1405
85. Management of Peripheral Vascular Disease 1413
86. Antithrombotic and Fibrinolytic Management of Patients with Unstable Coronary Artery Disease 1431
87. Antithrombotic and Thrombolytic Treatment of Cerebrovascular Disease 1461
88. Thrombolytic Therapy: Foundations and Clinical Results 1475
89. Practical Aspects of Anticoagulant Therapy 1497
90. Molecular Mechanisms of Platelet Activation and Inhibition 1517
91. New Antithrombotic Drugs 1529
Index

등록된 상품문의

상품문의 쓰기 새 창 더보기

상품문의가 없습니다.