High-Dose Cancer Therapy: Pharmacology. Hematopoietins. Stem Cells > 약물학/약리학

A comprehensive text that explores dose intensive therapy for a broad range of malignancies. It covers the biology of hematopoiesis, biology and clinical applications of growth factors, pharmacology of cancer therapy, management details for many cancers at high dose, and the unique complications of high dose therapy and their management. For hematologists and oncologists. Includes an errata sheet.

Sect. I Strategies for the Use of Agents at High Dose
1 Pharmacologic Strategies for High-Dose Chemotherapy 3
2 Preclinical Models for High-Dose Therapy 14
3 Pharmacokinetics 43
4 Strategies for the Use of Total Body Irradiation as Systemic Therapy in Leukemia and Lymphoma 61
5 Radioimmunoglobulin Therapy 84
6 What Is the Best Strategy for Bone Marrow Transplantation Cancer? 124
7 Analysis of Economic Issues 127
Sect. II Reestablishing Hematopoiesis after Dose-Intensive Therapy Transplantation
8 The Hematopoietic Microenvironment 143
9 Reconstitution of Hematopoiesis Following Allogeneic Bone Marrow Transplantation 151
10 Autologous Bone Marrow Transplantation 162
11 Reestablishing Hematopoiesis After Dose-Intensive Therapy with Peripheral Stem Cells 182
12 High-Dose Cancer Therapy Without Stem Cell Support - Human Solid Tumors 195
13 Immunologic Reconstitution After High-Dose Chemoradiotherapy and Allogeneic or Autologous Bone Marrow or Peripheral Blood Hematopoietic Stem Cell Transplantation 211
Marrow Contamination
14 Marrow Contamination: Detection and Significance 226
15 Bone Marrow Purging 249
16 Marrow Contamination: Positive Selection 276
Growth Factors
17 Hematopoietic Growth Factors 289
18 Granulocyte-Monocyte Colony-Stimulating Factor 314
19 Delivery of High-Dose Chemotherapy with Recombinant Human Granulocyte Colony-Stimulating Factor Support 333
20 Macrophage Colony-Stimulating Factor: Biology and Clinical Applications 344
21 Interleukin 3: General Biology, Preclinical and Clinical Studies 362
22 Erythropoietin in High-Dose Chemotherapy 385
Sect. III Laboratory and Clinical Support for Dose-Intensive Therapy
23 Nursing for Patients Receiving High-Dose Chemotherapy with Hematopoietic Rescue 405
24 Hickman Line Management 419
25 Blood Bank Support in Patients Undergoing High-Dose Cancer Therapy 437
26 Infectious Diseases 456
27 Pulmonary Complications of Bone Marrow Transplantation 473
28 Hepatic Complications of Bone Marrow Transplantation 487
29 The Cardiovascular System and Anticancer Therapy 505
30 Dermatology 518
31 Genitourinary, Gastrointestinal, and Other Complications 547
32 Gonadal Complications 555
Sect. IV Clinical Applications of High-Dose Therapy
33 High-Dose Therapy for Acute Myelocytic Leukemia 569
34 High-Dose Therapy in Acute Lymphoblastic Leukemia 607
35 Intensive Therapy of Chronic Myelogenous Leukemia 619
36 High-Dose Therapy and Allogeneic Bone Marrow Transplantation in Chronic Lymphocytic Leukemia 626
37 High-Dose Therapy, Autologous Stem Cells, and Hematopoietic Growth Factors for the Management of Multiple Myeloma 638
38 Autologous Bone Marrow Transplantation for Hodgkin's Disease 651
39 High-Dose Therapy for the Treatment of Non-Hodgkin's Lymphoma 662
40 High-Dose Therapy in Burkitt's Lymphoma 677
41 High-Dose Chemotherapy in the Management of Malignant Germ Cell Tumors 690
42 Dose-Intensive Therapy in Breast Cancer 701
43 High-Dose Chemotherapy with Autologous Bone Marrow Support for Lung Cancer 719
44 High-Dose Chemotherapy and Autologous Marrow Transplantation for Common Epithelial Ovarian Cancer 729
45 Myeloablative Treatment Supported by Marrow Infusions for Children with Neuroblastoma 735
46 Dose-Intensive Therapy for Advanced Melanoma 750
47 High-Dose Therapy for Brain Tumors: Rationale, Results, and Revelations 755
48 Autologous Bone Marrow Transplantation for Miscellaneous Tumors 763
Index 773

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