Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside,8/e > Cardiology

Fully updated from cover to cover, Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. 

Key Features

• Packs each chapter with the latest information necessary for optimal basic research as well as patient care. 

• Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. 

• Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy,  cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. 

• Includes 47 new chapters covering both basic science and clinical topics. 

• Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. 

• Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. 

• Recipient of a 2018 Highly Commended award from the British Medical Association. 

• Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Author Information

Edited by Jose Jalife, MD, PhD, Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. and William Gregory Stevenson, MD, Director, Cardiac Arrhythmia Program, Cardiovascular Division, Brigham and Women's Hospital; Professor of Medicine Harvard Medical School, Boston, MA

1   Voltage-Gated Sodium Channels and Electrical Excitability of the Heart
2 Voltage-Gated Calcium Channels
3   Voltage-Regulated Potassium Channels
4   Molecular Regulation of Cardiac Inward Rectifier Potassium Channel
5   Mammalian Calcium Pumps in Health and Disease
6   Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function
7   Organellar Ion Channels and Transporters
8   Gap Junctional Connexin 43: Novel Insights from the New Millennium and their Clinical Implications
9   Computational modeling and simulation for human cardiac electrophysiology: From induced pluripotent stem-cell derived cardiomyocytes to adult cardiomyocytes
10   Regulation of Cardiac Calcium Channels
11   Molecular Genetics of ATP-Sensitive Potassium Channels in Cardiovascular Diseases
12   Role of Enhancers in Transcriptional Regulation of Cardiac Electrical Activity
13   Functional characterization of ion channel gene variants in sudden unexplained natural death
14 Stretch-Activated Potassium Channels in the Human Heart: Pathophysiologic and Clinical Significance
15   Connexins and Pannexins in Cardiovascular Disease
16   Excitation-Contraction Coupling
17   Ion Channel Trafficking in the Heart
17   Ion Channel Trafficking in the Heart
18   Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5
19   Connecting Cardiac Excitation to the Atomic Interactions of Ion Channels
20   Macromolecular Complexes and Cardiac Potassium Channels
21   Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias
22   The Intercalated Disc: A Molecular Network That Integrates Electrical Coupling, Intercellular Adhesion and Cell Excitability
23   Function and Dysfunction of Ion Channel Membrane Trafficking and Post Translational Modification
24 Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling
25   Coupled Oscillators and Sinoatrial Pacemaker Activity
25   Coupled Oscillators and Sinoatrial Pacemaker Activity
26   Mapping of Cardiac Action Potentials in Zebrafish to Assess Genetic Variants
27   Cell-to-Cell Communication and Impulse Propagation
28   Mechanisms of Normal and Dysfunctional Sinoatrial Nodal Excitability and Propagation
29   Cell Biology of the Specialized Cardiac Conduction System
30 Computational Predictions of Drug-Induced Arrhythmias
31 Global Optimization Approaches to Generate Dynamically Robust Electrophysiological Models
32   Calcium Signaling in Cardiomyocyte Models with Realistic Geometries
33   Theory of Rotors and Arrhythmias
34   Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associated with Arrhythmic Risk Markers
35   Computational Approaches for Accurate Rotor localization in the Human Atria
36 Modeling the Aging Heart
37   Electromechanical Vortex Filaments During Cardiac Fibrillation
38   Innervation of the Sinoatrial Node
39   Autonomic and Oxidant Regulation of Cardiac Sodium Currents: Mechanisms and Consequences
40  Neural Activity and Atrial Tachyarrhythmias
41 Sympathetic Modulation of Cardiac Electrophysiology
42 Role of the Autonomic Nervous System in Atrial Fibrillation
43    Rotational and Focal Sources of Atrial Fibrillation:  Scientific Rationale and Comparative Clinical Mapping
44 Nonivasive Frequency-Phase Mapping of Atrial Fibrillation
45 Mechanistic approaches for persistent AF ablation
46 Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation
47 Genetics of Atrial Fibrillation
48 Mechanisms in Genetic Sodium Channel Diseases
49   Genetic, Ionic and Cellular Mechanisms Underlying the J Wave Syndromes
50 Inheritable Potassium Channel Diseases
51 Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation
52   Dominant Frequency as a Tool for Personalized Monitoring of Atrial fibrillation Progression and Upstream Therapy
53   Pharmacogenomics of Cardiac Arrhythmias
54   Screening Drugs for Myocardial Disease in Vivo with Zebrafish
55   Gene Therapy for Atrial Fibrillation
56   Cardiac Remodeling and Regeneration
57   High-Throughput Optical Mapping of 2-Dimensional hiPSC-CM Platforms for Drug Discovery and Cardiotoxicity Testing
58   Functional Cardiac Fibroblasts Derived from Human Pluripotent Stem Cells via Second Heart Field Progenitors
59   The challenges of human iPSC-CM technology: Increasingly complex approaches improve cell maturation and relevance to modelling human cardiac disease
60   Assessment of the Patient With a Cardiac Arrhythmia
61  Differential Diagnosis of Narrow and Wide Complex Tachycardias
62 Electrocardiographic Monitoring: Short,  Long-Term Recording
63  Personal Cardiac Monitoring
64 Computed Tomography for Electrophysiology
65 Magnetic Resonance Imaging for Electrophysiology
66 Intracardiac Echocardiography for Electrophysiology
67  Autonomic Nervous System Assessment for Syncope and Arrhythmia Risk
68 Noninvasive Electrocardiographic Imaging of Arrhythmogenic Substrates and Arrhythmias
69 Genetic Testing
70 Supraventricular Tachycardias:  Diagnostic Maneuvers in the Electrophysiology Laboratory
71 Atrial Tachycardia
72 Atrioventricular Nodal Reentrant Tachycardia
73 Junctional Tachycardia
74 Preexcitation, Atrioventricular Reentry, Variants
75 Atrial Fibrillation: Mechanisms, Clinical Features, and Management
76 Ablation for Atrial Fibrillation
77   Left Atrial Appendage Management
78   Typical and Atypical Atrial Flutter: Mapping and Ablation
79 Sudden Cardiac Death in Adults
80 Premature Ventricular Complexes
81  Outflow Tract Ventricular Tachyarrhythmias: Mechanisms, Clinical Features, and Management
82 PVC Ablation with Anatomic Guidance:  Papillary Muscle, Moderator Band and Valve Annulus Sites
83 Fascicular Ventricular Arrhythmias
84 Bundle Branch Reentry Tachycardia
85 Ischemic Heart Disease
86 Ablation of Post-Myocardial Infarction Ventricular Tachycardia 
87 Ventricular Tachycardia in Patients with Dilated Cardiomyopathy
88 Lamin A/C, Noncompaction and Other Genetic Cardiomyopathies with Ventricular Arrhythmias
89 Ventricular Arrhythmias in Hypertrophic Cardiomyopathy: Sudden Death, Risk Stratification, and Prevention With Implantable Defibrillators
90 Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
91  Catecholaminergic Polymorphic Ventricular Tachycardia
92 Arrhythmias and Conduction Disturbances in Noncompaction Cardiomyopathy
93   Ventricular Arrhythmias in Takotsubo Cardiomyopathy
94 Mitral Valve Prolapse, ventricular arrhythmias and Sudden Death
95 Brugada Syndrome
96   Long and Short QT Syndromes
97 Andersen-Tawil Syndrome
98   Timothy Syndrome
99   J-Wave Syndromes
100   Idiopathic and Short-Coupled Ventricular Fibrillation
101 Mapping and Ablation of Ventricular Fibrillation
102   Drug-Induced Ventricular Arrhythmias
103   Syncope
104   Sinus Node Abnormalities
105   Postural Orthostatic Tachycardia Syndrome
106 Atrioventricular Block
107   Sex Differences in Arrhythmias
108   Sudden Cardiac Deaths in Athletes, Including Commotio Cordis
109   Cardiac Sarcoidosis
110   Sleep-Disordered Breathing and Arrhythmias
111   Ventricular Assist Devices and Cardiac Transplant Recipients
112   Arrhythmia in Neurologic Disease
113   Cancer Therapy Related Arrhythmias
114   Arrhythmias in the Pediatric Population
115   Supraventricular Tachycardias in Congenital Heart Disease
116   Ventricular Arrhythmias in Congenital Heart Disease
117   Antiarrhythmic Drugs
118   Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death
119   Oral Anticoagulants
120  Implantable Pacemakers
121 Implantable Cardioverter Defibrillators: Technical Aspects
122   Transvenous Implantable Cardioverter Defibrillator: Clinical Aspects
123   Subcutaneous Implantable Cardioverter Defibrillators
124   Wearable Defibrillators
125   Cardiac Resynchronization
126   Management of Implanted Device Infections
127   Electrogram Recording and Signal Processing
128   Electroanatomic Mapping for Arrhythmias
129   Mapping Scar-Related Arrhythmias
130   Radiofrequency Ablation
131   Cryoablation and Other Radiofrequency Alternatives
132   Transvascular Ethanol Ablation
133 Cardiac Radioablation
134 Epicardial Approach in Electrophysiology
135  Surgery for Atrial Fibrillation and Other Supraventricular Tachycardias
136   Surgery for Ventricular Arrhythmias
137 Neuromodulation for the Treatment of Arrhythmias