The Liver: Biology and Pathobiology, 5/e > Gastroenterology

Painstakingly revised, this edition includes 60 new chapters. As in previous editions, a section called Horizons summarizes advances of extraordinary nature in areas expected to have a substantial impact on hepatology. The Fifth Edition’s Horizons section includes emerging topics such as tissue engineering of the liver, liver-directed gene therapy, decoding the liver cancer genome, and imaging cellular proteins and structure.

To preserve essential background information which has not changed while making room for the panoply of major new contributions to understanding of liver disease, 14 chapters from the previous edition are freely available online at gastrohep.com.   To view these chapters visit - http://www.gastrohep.com/theliver/

1 Organizational Principles of the Liver

Joe W. Grisham

2 Embryonic Development of the Liver

Roque Bort and Kenneth S. Zaret

PART TWO THE CELLS

3 Microtubules, Actin Filaments and Motor-mediated Vesicular Transport

Ronald R. Marchelletta and Sarah F. Hamm-Alvarez

4 Molecular Motors

Peter Satir

5 Ion Pumps and Molecular Motors: P-, F-, and V-type ATPases

Sarah Bond, Daniel J. Cipriano, and Michael Forgac

6 Hepatocyte Surface Polarity: Its Dynamic Maintenance and Establishment

Lelita T. Braiterman and Ann L. Hubbard

7 Endocytosis as an Essential Process in Liver Function and Pathology

Barbara Schroeder and Mark McNiven

8 Membrane Transport in Hepatocellular Secretion

Susan Chi and Mark McNiven

9 Mitochondria

Kastuei Mitra

10  Nuclear Pore Complex

Joseph S. Glavy

11 Protein Maturation and Processing at the Endoplasmic Reticulum

Ramanujan S. Hegde

12 Protein Degradation and the Lysosomal System

Susmita Kaushik and Ana Maria Cuervo

13 Peroxisome Assembly, Degradation, and Disease

Peter K. Kim

14 Gap and Tight Junctions in Liver: Composition, Regulation, and Function

Takashi Kojima, Norimasa Sawada, Hiroshi Yamaguchi, Alfredo G. Fort, and David C. Spray

SECTION A HEPATOCYTE

15 Copper Metabolism and the Liver

Michael L. Schilsky and Dennis J. Thiele

16 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis

Tracey A. Rouault, Victor Gordeuk, and Gregory Anderson

17 Disorders of Bilirubin Metabolism

Namita Roy Chowdhury and Jayanta Roy Chowdhury

GH4.21. The porphyrias
Peter N. Meissner, Richard J. Hift, Ralph E. Kirsch

18 Hepatic fatty acid metabolism and dysfunction

David L. Silver

19 Lipoprotein Metabolism and Cholesterol Balance

David E. Cohen

SECTION B BILE SECRETION

20 Bile Acids and the Enterohepatic Circulation

Alan F. Hofmann

21 Hepatocyte Basolateral Membrane Organic Anion Transporters

Jo. H. Choi, John W. Murray, and Allan W. Wolkoff

22 Nuclear Receptors Regulate Bile Acid Synthesis

Guorong Xu and Gerald Salen

GH4.27. Hormonal regulation of bile secretion
Francis R. Simon

GH4.28. Nucleotide transport and regulation of bile formation
Richard M. Roman and J. Gregory Fitz

23 The Function of the Canalicular Membrane in Bile Formation and Secretion

Ronald P.J. Oude Elferink and Coen C. Paulusma

24 Apical Recycling of Canalicular ABC Transporters

Yoshiyuki Wakabayashi and Irwin M. Arias

25 Cholangiocyte Functions in Health and Disease: The Ciliary Connection

Anatoliy I. Masyuk, Tatyana V. Masyuk, and Nicholas F. LaRusso

SECTION C SINUSOIDAL CELLS

26 The Hepatic Sinusoidal Endothelial Cell: Morphology, Function, and Pathobiology

Laurie D. DeLeve

GH4.30. Endothelial and pit cells
Filip Braet, Dianzhong Luo, Ilan Spector, David Vermijlen, Eddie Wisse

27 Fenestrations in the Liver Sinusoidal Endothelial Cell

Victoria C. Cogger and David G. Le Couteur

28 Hepatic Stellate Cells

Marcos Rojkind and Karina Reyes-Gordillo

29 Hepatic Fibrosis

Ram´on Bataller and David A. Brenner

30 Matrix

Giuliano Ramadori and Jozsef Dudas

PART THREE INTERRELATED CELL FUNCTIONS

31 Insulin Resistance

Gerald I. Shulman and Varman Samuel

32 Ca2+ Signaling in the Liver

M. Fatima Leite, Mateus T. Guerra, and Michael H. Nathanson

GH4.35 Synthesis of and signalling through D-3 phosphoinositides
Rial A Christensen, Isabel De Aos Scherpenseel, Lyuba Varticovski

GH4.39. Nitric oxide in the liver
Mark G. Clemens

33 Role of Intracellular Iron Movement and Oxidant Stress in Hepatocellular Injury

John J. Lemasters, Akira Uchiyama, Jae-Sung Kim, Kazuyoshi Kon, and Hartmut Jaeschke

GH4.18. Hypoxic, Ischemic and reperfusion injury to liver
John J. Lemasters

GH4.19. Protective mechanisms against reactive oxygen species
Masayasu Inoue

34 Regulatory Pathways of Liver Gene Expression: The Central Role of Cyclic AMP

Giuseppe Servillo, Maria Agnese Della Fazia, and Paolo Sassone-Corsi

35 AMPK: Central Regulator of Glucose and Lipid Metabolism  

Maria M. Mihaylova and Reuben J. Shaw

GH3.16. Energy Metabolism

Sam Seifter and Sasha Englard

36 Liver Regeneration

Nelson Fausto

GH4.40. Interleukin-6 signaling during the acute-phase response of the liver
Johannes G. Bode, Peter C. Heinrich

GH4.43. Hepatocyte growth factor: its role in hepatic growth and pathobiology
Reza Zarnegar, Marie C. Defrances, George K. Michalopoulos

37 Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver

Stefano Fumagalli and George Thomas

GH4.5. Gene regulation and in vivo function of liver transcription factors
Robert H. Costa, AI-Xuan Le Holternan, Francisco M. Rausa, Guy R. Adami

38 Liver Repopulation by Cell Transplantation and the Role of Stem Cells

David A. Shafritz, Michael Oertel, Mariana D. Dabeva, and Markus Grompe

PART FOUR RELATION TO OTHER ORGANS

39 Hepatic Encephalopathy

Roger F. Butterworth and Javier Vaquero

40 The Kidney in Liver Disease

Moshe Levi

41 Critical Role of the Liver in Coagulation

Robert Fathke, Ze Peng, Basil Golding, and Chava Kimchi-Sarfaty

PART FIVE PATHOBIOLOGICAL ANALYSIS

42 Inheritable Cholestatic Disorders

Paul Gissen and Alex S. Knisely

GH4.48. Alpha 1-Antitrypsin deficiency
David H. Perlmutter

43 Adaptive Regulation of Hepatocyte Transporters in Cholestasis

James L. Boyer

44 Pathogenesis of Portal Hypertension

Roberto J. Groszmann and Juan G. Abraldes

45 Non-alcoholic Fatty Liver Disease: A Pathophysiological Perspective

Michael Fuchs and Arun J. Sanyal

46 Pathophysiology of Alcoholic Liver Disease

Natalia Nieto and Marcos Rojkind

47 Inflammation and Drug-induced Liver Injury

Robert A. Roth and Patricia E. Ganey

48 Hepatocyte Apoptosis

Cynthia R.L. Webster

49 Back to the Future: A Backward Glance at the Forward Progress of Hepatitis Virus Research

Harvey J. Alter

50 Molecular Biology of Hepatitis Viruses

Christoph Seeger, Michael M.C. Lai, and William S. Mason

51 Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis

Carlo Ferrari and Mario Mondelli

GH4.41. Innate immune sensing and the toll-like receptors
Bruce Beutler

52 Clinical Implications of the Molecular Biology of Hepatitis B Virus

Timothy M. Block, Ju-Tao Guo, and Thomas W. London

53 Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection

Stanley M. Lemon, Patrizia Farci, and Marc G. Ghany

54 Current and Future Therapy for Hepatitis B and C

Gary L. Davis and Jean-Michel Pawlotsky

55 Biological Principles and Clinical Issues Underlying Liver Transplantation for Virus-induced

End-stage Liver Disease

James R. Burton Jr, Hugo R. Rosen, and Paul Martin

PART SIX HORIZONS

56 Tissue Engineering of the Liver

Gregory H. Underhill, Salman R. Khetani, Alice A. Chen, and Sangeeta N. Bhatia

57 Aging and the Uncertain Roles of Sirtuins

Fred J. Dice

58 The Liver Proteome

Laura Beretta

59 Liver-directed Gene Therapy

Betsy T. Kren, Clifford J. Steer, Namita Roy Chowdhury, and Jayanta Roy Chowdhury

GH4.63. Novel strategies for manipulating hepatic gene expression in vivo
Marxa L. Figueiredo, Eric P. Sandgren

60 Decoding the Liver Cancer Genome

Ju-Seog Lee and Snorri S. Thorgeirsson

61 Genome-wide Expression Profiling of Human Hepatocellular Carcinoma

Anuradha Budhu and Xin Wei Wang

62 Cell Cycle Control in the Liver

Jeffrey H. Albrecht and Lisa K. Mullany

63 miRNAs and Liver Biology

Charles E. Rogler and Leslie E. Rogler

64 Imaging Cellular Proteins and Structures: Smaller, Brighter, and Faster

Erik Snapp

65 Zebrafish as a Model System for the Study of Liver Development and Disease

Randolph P. Matthews

66 The Hepatocyte and the Cancer Cell: Dr Jekyll and Mr Hyde

Jean-Pierre Gillet, Michael M. Gottesman, and Mitsunori Okabe

67 The Role of Endocannabinoids and Their Receptors in the Control of Hepatic Functions

George Kunos, Douglas Osei-Hyiaman, S´andor B´atkai, P´al Pacher, Bin Gao, Won-Il Jeong, Jie Liu, and

Gregorz Godlewski

68 Telomeres and Aging, Cancer, and Hepatic Fibrosis

Hans L. Tillmann, Ruben R. Plentz, Yvonne Begus-Nahrmann, Andr´e Lechel, and Lenhard K. Rudolph

69 Treatment of Cirrhosis with Vitamin A-coupled Liposomes Carrying siRNA against Heat Shock

Protein 47

Yoshiro Niitsu, Yasushi Sato, Kazuyuki Murase, and Junji Kato

70 The “Green Liver” and Transcriptional Regulation of Phase II Detoxification Genes

Christopher Johnson and Jonathan Arias

Index